Some key players like Noussair Mazraoui, Kobbie Mainoo, Manuel Ugarte, and several others may be absent from the lineup.
Defenders Luke Shaw and Tyrell Malacia are still out and have no return dates.
Alejandro Garnacho has a slight knee injury, while Rasmus Hojlund also had an issue and had to miss some training with Denmark during the break.
United have the biggest concern at left-back, where Jonny Evans may have to deputize this weekend.